Formation of C(sp 2 )Boronate Esters by Borylative Cyclization of Alkynes Using BCl 3 | Zendy

Warner Andrew J. | Zendy; Lawson James R. | Zendy; Fasano Valerio | Zendy; Ingleson Michael J. | Zendy

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Formation of C(sp 2 )Boronate Esters by Borylative Cyclization of Alkynes Using BCl 3

Author(s) -

Warner Andrew J.,

Lawson James R.,

Fasano Valerio,

Ingleson Michael J.

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201505810

Subject(s) - chemistry , electrophile , intermolecular force , combinatorial chemistry , alkyne , organic chemistry , medicinal chemistry , molecule , catalysis

BCl 3 is an inexpensive electrophile which induces the borylative cyclization of a wide range of substituted alkynes to regioselectively form polycycles containing synthetically versatile C(sp 2 )boronate esters. It proceeds rapidly, with good yields and is compatible with a range of functional groups and substitution patterns. Intermolecular 1,2‐carboboration of alkynes is also achieved using BCl 3 to generate trisubstituted vinyl boronate esters.

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