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Lanthanide Luminescence Modulation by Cation–π Interaction in a Bioinspired Scaffold: Selective Detection of Copper(I)
Author(s) -
Isaac Ma,
Denisov Sergey A.,
Roux Amandine,
Imbert Daniel,
Jonusauskas Gediminas,
McClenaghan Nathan D.,
Sénèque Olivier
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201505733
Subject(s) - terbium , luminescence , lanthanide , copper , chemistry , moiety , microsecond , fluorescence , luminescent measurements , population , ion , combinatorial chemistry , nanotechnology , photochemistry , materials science , stereochemistry , optoelectronics , organic chemistry , physics , demography , quantum mechanics , astronomy , sociology
Abstract A prototype luminescent turn‐on probe for Cu + (and Ag + ) is described, harnessing a selective binding site (log K ass =9.4 and 7.3 for Cu + and Ag + , respectively) based on the coordinating environment of the bacterial metallo‐chaperone CusF, integrated with a terbium‐ion‐signaling moiety. Cation–π interactions were shown to enhance tryptophan triplet population, which subsequently sensitized, on the microsecond timescale, the long‐lived terbium emission, offering a novel approach in bioinspired chemosensor design.