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A Stimuli‐Responsive Rotaxane–Gold Catalyst: Regulation of Activity and Diastereoselectivity
Author(s) -
Galli Marzia,
Lewis James E. M.,
Goldup Stephen M.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201505464
Subject(s) - rotaxane , catalysis , selectivity , chemistry , ligand (biochemistry) , yield (engineering) , photochemistry , materials science , organic chemistry , molecule , receptor , supramolecular chemistry , biochemistry , metallurgy
A rotaxane‐based Au catalyst was developed and the effect of the mechanical bond on its behavior was studied. Unlike the non‐interlocked thread, the rotaxane requires a catalytically innocent cofactor, the identity of which significantly influences both the yield and diastereoselectivity of the reaction. Under optimized conditions, Au I (the catalyst), Ag I (to abstract the Cl − ligand), and Cu I (the cofactor) combine to produce a catalyst with excellent activity and selectivity.
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