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Enantioselective ortho ‐CH Cross‐Coupling of Diarylmethylamines with Organoborons
Author(s) -
Laforteza Brian N.,
Chan Kelvin S. L.,
Yu JinQuan
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201505204
Subject(s) - enantioselective synthesis , pinacol , chemistry , protecting group , stereochemistry , coupling (piping) , amino acid , combinatorial chemistry , catalysis , organic chemistry , biochemistry , materials science , alkyl , metallurgy
The commonly used para ‐nitrobenzenesulfonyl (nosyl) protecting group is employed to direct the CH activation of amines for the first time. An enantioselective ortho ‐CH cross‐coupling between nosyl‐protected diarylmethylamines and arylboronic acid pinacol esters has been achieved utilizing chiral mono‐ N ‐protected amino acid (MPAA) ligands as a promoter.