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Selective Ruthenium‐Catalyzed Hydrochlorination of Alkynes: One‐Step Synthesis of Vinylchlorides
Author(s) -
Dérien Sylvie,
Klein Hubert,
Bruneau Christian
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201505144
Subject(s) - ruthenium , alkyne , markovnikov's rule , catalysis , chemistry , atom economy , stereoselectivity , combinatorial chemistry , structural isomer , organic chemistry , regioselectivity
An unprecedented ruthenium‐catalyzed direct and selective alkyne hydrochlorination is reported and leads to vinylchlorides in excellent yields with atom economy. The reaction proceeds at room temperature from terminal alkynes and provides a variety of chloroalkenes. Only the regioisomer resulting from the formal Markovnikov addition is selectively formed. Mechanistic studies show the stereoselective syn addition of HCl to alkynes at room temperature and suggest a chloro hydrido Ru IV species as a key intermediate of the reaction.