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Cobalt(II)‐Catalyzed C sp 2 H Alkynylation/Annulation with Terminal Alkynes: Selective Access to 3‐Methyleneisoindolin‐1‐one
Author(s) -
Zhang LinBao,
Hao XinQi,
Liu ZhanJiang,
Zheng XinXiang,
Zhang ShouKun,
Niu JunLong,
Song MaoPing
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201504962
Subject(s) - annulation , alkynylation , cobalt , catalysis , chemistry , substrate (aquarium) , salt (chemistry) , combinatorial chemistry , terminal (telecommunication) , denticity , medicinal chemistry , organic chemistry , computer science , crystal structure , computer network , oceanography , geology
A highly efficient cobalt(II)‐catalyzed alkynylation/annulation of terminal alkynes assisted by an N,O‐bidentate directing group is described. This protocol is characterized by wide substrate scope utilizing cheap cobalt catalysts, and offers a new approach to 3‐methyleneisoindolin‐1‐one, which can be converted into an oxadiazine salt in one step. Moreover, the directing group could be removed in three steps.