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Palladium‐Catalyzed Direct Cyclopropylation of Heterocycles
Author(s) -
Wu Xiaojin,
Lei Chuanhu,
Yue Guizhou,
Zhou Jianrong Steve
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201504735
Subject(s) - palladium , catalysis , chemistry , halide , radical , oxidative addition , photochemistry , combinatorial chemistry , organic chemistry
Many 1,3‐azoles and thiophenes are directly cyclopropylated in the presence of a simple palladium catalyst. The relative configuration on the three‐membered rings is retained in the products. Thus, the cyclopropyl–halide bond undergoes concerted oxidative addition to palladium(0) and cyclopropyl radicals are not involved in the productive pathway.