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Carbamate‐Catalyzed Enantioselective Bromolactamization
Author(s) -
Cheng Yi An,
Yu Wesley Zongrong,
Yeung YingYeung
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201504724
Subject(s) - enantioselective synthesis , stereocenter , carbamate , catalysis , amide , chemistry , organic chemistry , ethanol , ethyl carbamate , combinatorial chemistry , food science , wine
A highly facile, efficient, and enantioselective bromolactamization of olefinic amides was effected by a carbamate catalyst and ethanol additive. The amide substrates underwent N‐cyclization predominantly to give a diverse range of enantioenriched bromolactam products containing up to two stereogenic centers.