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Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin‐3‐ones Bearing Quaternary Stereocenters
Author(s) -
Liu RenRong,
Ye ShiChun,
Lu ChuanJun,
Zhuang GuiLin,
Gao JianRong,
Jia YiXia
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201504697
Subject(s) - stereocenter , enantioselective synthesis , annulation , chemistry , catalysis , redox , organocatalysis , combinatorial chemistry , phosphoric acid , organic chemistry
The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin‐3‐one derivatives bearing quaternary stereocenters at the C2 position were afforded in good yields and excellent enantioselectivities (up to 96 % ee ) from readily available starting materials.