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Metal‐Free Radical [2+2+1] Carbocyclization of Benzene‐Linked 1, n ‐Enynes: Dual C(sp 3 )H Functionalization Adjacent to a Heteroatom
Author(s) -
Hu Ming,
Fan JianHong,
Liu Yu,
Ouyang XuanHui,
Song RenJie,
Li JinHeng
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201504603
Subject(s) - heteroatom , benzene , annulation , chemistry , surface modification , metal , stereochemistry , medicinal chemistry , photochemistry , organic chemistry , ring (chemistry) , catalysis
A new metal‐free oxidative radical [2+2+1] carbocyclization of benzene‐linked 1, n ‐enynes with two C(sp 3 )H bonds adjacent to the same heteroatom is described. This method achieves two C(sp 3 )H oxidative functionalizations and an annulation, thus providing efficient and general access to a variety of fused five‐membered carbocyclic hydrocarbons.