Tandem Chemoselective Suzuki–Miyaura Cross‐Coupling Enabled by Nucleophile Speciation Control | Zendy

Seath Ciaran P. | Zendy; Fyfe James W. B. | Zendy; Molloy John J. | Zendy; Watson Allan J. B. | Zendy

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Tandem Chemoselective Suzuki–Miyaura Cross‐Coupling Enabled by Nucleophile Speciation Control

Author(s) -

Seath Ciaran P.,

Fyfe James W. B.,

Molloy John J.,

Watson Allan J. B.

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201504297

Subject(s) - chemoselectivity , nucleophile , transmetalation , tandem , chemistry , combinatorial chemistry , boronic acid , oxidative addition , coupling (piping) , organic chemistry , catalysis , materials science , composite material , metallurgy

Control of boronic acid speciation is presented as a strategy to achieve nucleophile chemoselectivity in the Suzuki–Miyaura reaction. Combined with simultaneous control of oxidative addition and transmetalation, this enables chemoselective formation of two CC bonds in a single operation, providing a method for the rapid preparation of highly functionalized carbogenic frameworks.

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