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Selective Michael Reaction Controlled by Supersilyl Protecting Group
Author(s) -
Izumiseki Atsuto,
Yamamoto Hisashi
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503574
Subject(s) - michael reaction , reagent , protecting group , chemistry , methacrylate , combinatorial chemistry , organic chemistry , catalysis , alkyl , polymer , copolymer
Abstract Selective Michael reaction of organolithium reagents to supersilyl methacrylate is reported. The method was able to control a single and double Michael addition. The successful termination of the process using the supersilyl protecting group allows for the controlled, chemoselective, and diastereoselective Michael reaction.