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Direct Ruthenium‐Catalyzed Hydrogenation of Carboxylic Acids to Alcohols
Author(s) -
Cui Xinjiang,
Li Yuehui,
Topf Christoph,
Junge Kathrin,
Beller Matthias
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503562
Subject(s) - triphos , ruthenium , chemistry , catalysis , carboxylic acid , organic chemistry , lewis acids and bases , substrate (aquarium) , combinatorial chemistry , oceanography , geology
Abstract The “green” reduction of carboxylic acids to alcohols is a challenging task in organic chemistry. Herein, we describe a general protocol for generation of alcohols by catalytic hydrogenation of carboxylic acids. Key to success is the use of a combination of Ru(acac) 3 , triphos and Lewis acids. The novel method showed broad substrate tolerance and a variety of aliphatic carboxylic acids including biomass‐derived compounds can be smoothly reduced.