Premium
Nickel‐Catalyzed Chemo‐, Regio‐ and Diastereoselective Bond Formation through Proximal CC Cleavage of Benzocyclobutenones
Author(s) -
JuliáHernández Francisco,
Ziadi Asraa,
Nishimura Akira,
Martin Ruben
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503461
Subject(s) - catalysis , nickel , cleavage (geology) , chemistry , bond cleavage , intermolecular force , stereochemistry , regioselectivity , molecule , organic chemistry , materials science , fracture (geology) , composite material
The first catalytic intermolecular proximal C1C2 cleavage of benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo‐, regio‐ and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons.