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Copper‐Catalyzed Trifluoromethylazidation of Alkynes: Efficient Access to CF 3 ‐Substituted Azirines and Aziridines
Author(s) -
Wang Fei,
Zhu Na,
Chen Pinhong,
Ye Jinxing,
Liu Guosheng
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503412
Subject(s) - catalysis , chemistry , copper , combinatorial chemistry , alkyne , medicinal chemistry , organic chemistry
A novel method for convenient access to CF 3 ‐containing azirines has been developed, and involves a copper‐catalyzed trifluoromethylazidation of alkynes and a photocatalyzed rearrangement. Both terminal and internal alkynes are compatible with the mild reaction conditions, thus delivering the CF 3 ‐containing azirines in moderate to good yields. The azirines can be converted into various CF 3 ‐substituted aziridines.