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Well‐Defined and Robust Rhodium Catalysts for the Hydroacylation of Terminal and Internal Alkenes
Author(s) -
Prades Amparo,
Fernández Maitane,
Pike Sebastian D.,
Willis Michael C.,
Weller Andrew S.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503208
Subject(s) - hydroacylation , alkene , rhodium , catalysis , chemistry , ligand (biochemistry) , terminal (telecommunication) , organic chemistry , medicinal chemistry , computer science , receptor , biochemistry , telecommunications
A Rh‐catalyst system based on the asymmetric ligand t Bu 2 PCH 2 P( o ‐C 6 H 4 OMe) 2 is reported that allows for the hydroacylation of challenging internal alkenes with β‐substituted aldehydes. Mechanistic studies point to the stabilizing role of both excess alkene and the OMe‐group.