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Catalytic Enantioselective Reaction of α‐Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts
Author(s) -
Kondo Masaru,
Nishi Tomoki,
Hatanaka Tsubasa,
Funahashi Yasuhiro,
Nakamura Shuichi
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503098
Subject(s) - enantioselective synthesis , catalysis , chemistry , imidazoline receptor , palladium , reaction conditions , organic chemistry , combinatorial chemistry , medicine
The catalytic enantioselective reaction of diphenylmethylidene‐protected α‐aminoacetonitriles with imines has been developed. Good yields and diastereo‐ and enantioselectivities were observed for the reaction of various imines using chiral bis(imidazoline)/Pd catalysts. The reaction of α‐aminonitriles with di‐ tert ‐butyl azodicarboxylate afforded chiral α,α‐diaminonitriles in high yields with high enantioselectivities.