Premium
Copper‐Catalyzed Intermolecular Asymmetric Propargylic Dearomatization of Indoles
Author(s) -
Shao Wen,
Li He,
Liu Chuan,
Liu ChenJiang,
You ShuLi
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201503042
Subject(s) - stereocenter , moiety , intermolecular force , alkyne , chemistry , catalysis , yield (engineering) , copper , combinatorial chemistry , stereochemistry , enantioselective synthesis , organic chemistry , molecule , materials science , metallurgy
The first copper‐catalyzed intermolecular dearomatization of indoles by an asymmetric propargylic substitution reaction was developed. This method provides a highly efficient synthesis of versatile furoindoline and pyrroloindoline derivatives containing a quaternary carbon stereogenic center and a terminal alkyne moiety with up to 86 % yield and 98 % ee .