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In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)
Author(s) -
Balog Julia,
Kumar Sacheen,
Alexander James,
Golf Ottmar,
Huang Juzheng,
Wiggins Tom,
AbbassiGhadi Nima,
Enyedi Attila,
Kacska Sandor,
Kinross James,
Hanna George B.,
Nicholson Jeremy K.,
Takats Zoltan
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502770
Subject(s) - in vivo , mass spectrometry , gastrointestinal tract , chemistry , chromatography , biology , biochemistry , microbiology and biotechnology
Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer‐related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.