Premium
Homodecoupled 1,1‐ and 1,n‐ADEQUATE: Pivotal NMR Experiments for the Structure Revision of Cryptospirolepine
Author(s) -
Saurí Josep,
Bermel Wolfgang,
Buevich Alexei V.,
Sherer Edward C.,
Joyce Leo A.,
Sharaf Maged H. M.,
Schiff Paul L.,
Parella Teodor,
Williamson R. Thomas,
Martin Gary E.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502540
Subject(s) - characterization (materials science) , chemistry , materials science , nanotechnology
Cryptospirolepine is the most structurally complex alkaloid discovered and characterized thus far from any Cryptolepis specie. Characterization of several degradants of the original, sealed NMR sample a decade after the initial report called the validity of the originally proposed structure in question. We now report the development of improved, homodecoupled variants of the 1,1‐ and 1,n‐ADEQUATE (HD‐ADEQUATE) NMR experiments; utilization of these techniques was critical to successfully resolving long‐standing structural questions associated with crytospirolepine.