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A pH‐Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window
Author(s) -
Wang Xiaojing,
Wu Yunkou,
Soesbe Todd C.,
Yu Jing,
Zhao Piyu,
Kiefer Garry E.,
Sherry A. Dean
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502497
Subject(s) - terbium , magnetization transfer , deprotonation , chemistry , magnetization , proton , nuclear magnetic resonance , molecule , interference (communication) , magnetic resonance imaging , ion , physics , organic chemistry , magnetic field , medicine , quantum mechanics , radiology , engineering , channel (broadcasting) , electrical engineering
A terbium‐based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.