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Palladium‐Catalyzed Hydroaminocarbonylation of Alkenes with Amines: A Strategy to Overcome the Basicity Barrier Imparted by Aliphatic Amines
Author(s) -
Zhang Guoying,
Gao Bao,
Huang Hanmin
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502405
Subject(s) - palladium , catalysis , chemistry , regioselectivity , alkyl , paraformaldehyde , organic chemistry , combinatorial chemistry
A novel and efficient palladium‐catalyzed hydroaminocarbonylation of alkenes with aminals has been developed under mild reaction conditions, and allows the synthesis of a wide range of N‐alkyl linear amides in good yields with high regioselectivity. On the basis of this method, a cooperative catalytic system operating by the synergistic combination of palladium, paraformaldehyde, and acid was established for promoting the hydroaminocarbonylation of alkenes with both aromatic and aliphatic amines, which do not react well under conventional palladium‐catalyzed hydroaminocarbonylation.