Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐ N ‐Propargylanilines by Rearrangement of a Propargyl Group | Zendy

Tokimizu Yusuke | Zendy; Oishi Shinya | Zendy; Fujii Nobutaka | Zendy; Ohno Hiroaki | Zendy

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Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐ N ‐Propargylanilines by Rearrangement of a Propargyl Group

Author(s) -

Tokimizu Yusuke,

Oishi Shinya,

Fujii Nobutaka,

Ohno Hiroaki

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201502256

Subject(s) - propargyl , substituent , aniline , chemistry , indole test , catalysis , nitrogen atom , medicinal chemistry , rearrangement reaction , cascade reaction , cycloisomerization , stereochemistry , combinatorial chemistry , group (periodic table) , organic chemistry

Gold catalysis enables direct construction of tetracyclic fused indolines through the migration of a propargyl substituent from an aniline nitrogen atom to the C3‐position of an indole from 2‐alkynyl‐ N ‐propargylanilines. This reaction provides rapid access to fused three‐dimensional indolines in a single operation with the formation of four bonds and three rings.

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