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Reliable Quantitative SERS Analysis Facilitated by Core–Shell Nanoparticles with Embedded Internal Standards
Author(s) -
Shen Wei,
Lin Xuan,
Jiang Chaoyang,
Li Chaoyu,
Lin Haixin,
Huang Jingtao,
Wang Shuo,
Liu Guokun,
Yan Xiaomei,
Zhong Qiling,
Ren Bin
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502171
Subject(s) - raman scattering , molecule , raman spectroscopy , nanoparticle , shell (structure) , nanotechnology , chemistry , quantitative analysis (chemistry) , adsorption , materials science , optics , chromatography , physics , organic chemistry , composite material
Quantitative analysis is a great challenge in surface‐enhanced Raman scattering (SERS). Core‐molecule‐shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods.