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Palladium(0)/PAr 3 ‐Catalyzed Intermolecular Amination of C(sp 3 )H Bonds: Synthesis of β‐Amino Acids
Author(s) -
He Jian,
Shigenari Toshihiko,
Yu JinQuan
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201502075
Subject(s) - amination , chemistry , catalysis , palladium , intermolecular force , catalytic cycle , medicinal chemistry , ligand (biochemistry) , bond cleavage , oxidative addition , organic chemistry , molecule , biochemistry , receptor
An intermolecular C(sp 3 )H amination using a Pd 0 /PAr 3 catalyst was developed. The reaction begins with oxidative addition of R 2 NOBz to a Pd 0 /PAr 3 catalyst and subsequent cleavage of a C(sp 3 )H bond by the generated PdNR 2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)‐catalyzed CH arylation reactions. The electron‐deficient triarylphosphine ligand is crucial for this C(sp 3 )H amination reaction to occur.