Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis | Zendy

Younai Ashkaan | Zendy; Zeng BiShun | Zendy; Meltzer Herbert Y. | Zendy; Scheidt Karl A. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis

Author(s) -

Younai Ashkaan,

Zeng BiShun,

Meltzer Herbert Y.,

Scheidt Karl A.

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201502011

Subject(s) - enantioselective synthesis , stereocenter , enamine , chemistry , catalysis , organocatalysis , combinatorial chemistry , organic chemistry , stereochemistry

Alstonine and serpentine are pentacyclic indoloquinolizidine alkaloids (referred to as “anhydronium bases”) containing three contiguous stereocenters. Each possesses interesting biological activity, with alstonine being the major component of a plant‐based remedy to treat psychosis and other nervous system disorders. This work describes the enantioselective total syntheses of these natural products with a cooperative hydrogen bonding/enamine‐catalyzed Michael addition as the key step.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research