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Self‐Assembly of Disorazole C 1 through a One‐Pot Alkyne Metathesis Homodimerization Strategy
Author(s) -
Ralston Kevin J.,
Ramstadius H. Clinton,
Brewster Richard C.,
Niblock Helen S.,
Hulme Alison N.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501922
Subject(s) - alkyne , metathesis , ring closing metathesis , acyclic diene metathesis , chemistry , combinatorial chemistry , organic chemistry , catalysis , polymerization , polymer
Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C 2 ‐symmetric marine‐derived bis(lactone) disorazole C 1 , a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.