Self‐Assembly of Disorazole C 1  through a One‐Pot Alkyne Metathesis Homodimerization Strategy | Zendy

Ralston Kevin J. | Zendy; Ramstadius H. Clinton | Zendy; Brewster Richard C. | Zendy; Niblock Helen S. | Zendy; Hulme Alison N. | Zendy

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Self‐Assembly of Disorazole C 1 through a One‐Pot Alkyne Metathesis Homodimerization Strategy

Author(s) -

Ralston Kevin J.,

Ramstadius H. Clinton,

Brewster Richard C.,

Niblock Helen S.,

Hulme Alison N.

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201501922

Subject(s) - alkyne , metathesis , ring closing metathesis , acyclic diene metathesis , chemistry , combinatorial chemistry , organic chemistry , catalysis , polymerization , polymer

Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne‐metathesis‐based homodimerization approach to natural products. In this approach to the cytotoxic C 2 ‐symmetric marine‐derived bis(lactone) disorazole C 1 , a highly convergent, modular strategy is employed featuring cyclization through an ambitious one‐pot alkyne cross‐metathesis/ring‐closing metathesis self‐assembly process.

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