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Highly Enantioselective Transfer Hydrogenation of Ketones with Chiral (NH) 2 P 2 Macrocyclic Iron(II) Complexes
Author(s) -
Bigler Raphael,
Huber Raffael,
Mezzetti Antonio
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501807
Subject(s) - enantioselective synthesis , chemistry , catalysis , ligand (biochemistry) , yield (engineering) , transfer hydrogenation , macrocyclic ligand , medicinal chemistry , kinetic resolution , combinatorial chemistry , stereochemistry , organic chemistry , molecule , receptor , materials science , biochemistry , ruthenium , metallurgy
Abstract Bis(isonitrile) iron(II) complexes bearing a C 2 ‐symmetric diamino (NH) 2 P 2 macrocyclic ligand efficiently catalyze the hydrogenation of polar bonds of a broad scope of substrates (ketones, enones, and imines) in high yield (up to 99.5 %), excellent enantioselectivity (up to 99 % ee ), and with low catalyst loading (generally 0.1 mol %). The catalyst can be easily tuned by modifying the substituents of the isonitrile ligand.