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A Versatile Room‐Temperature Route to Di‐ and Trisubstituted Allenes Using Flow‐Generated Diazo Compounds
Author(s) -
Poh JianSiang,
Tran Duc N.,
Battilocchio Claudio,
Hawkins Joel M.,
Ley Steven V.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501538
Subject(s) - diazo , chemistry , functional group , combinatorial chemistry , flow chemistry , copper , allene , continuous flow , catalysis , organic chemistry , physics , mechanics , polymer
A copper‐catalyzed coupling reaction between flow‐generated unstabilized diazo compounds and terminal alkynes provides di‐ and trisubstituted allenes. This extremely mild and rapid transformation is highly tolerant of several functional groups.