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Self‐Assembled Fluorodendrimers Combine the Features of Lipid and Polymeric Vectors in Gene Delivery
Author(s) -
Wang Hui,
Wang Yitong,
Wang Yu,
Hu Jingjing,
Li Tianfu,
Liu Hongmei,
Zhang Qiang,
Cheng Yiyun
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501461
Subject(s) - gene delivery , transfection , biocompatibility , genetic enhancement , liposome , cytotoxicity , cationic polymerization , cationic liposome , nanotechnology , dna , polymer , gene , chemistry , vector (molecular biology) , biophysics , materials science , computational biology , biology , biochemistry , in vitro , recombinant dna , polymer chemistry , organic chemistry
An ideal vector in gene therapy should exhibit high serum stability, excellent biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here, we describe a class of low‐molecular‐weight fluorodendrimers for efficient gene delivery. These materials self‐assemble into uniform nanospheres and allow for efficient transfection at low charge ratios and very low DNA doses with minimal cytotoxicity. Our results demonstrate that these vectors combine the features of synthetic gene vectors such as liposomes and cationic polymers and present promising potential for clinical gene therapy.