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Rhodium(III)‐Catalyzed [3+2]/[5+2] Annulation of 4‐Aryl 1,2,3‐Triazoles with Internal Alkynes through Dual C(sp 2 )H Functionalization
Author(s) -
Yang Yuan,
Zhou MingBo,
Ouyang XuanHui,
Pi Rui,
Song RenJie,
Li JinHeng
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501260
Subject(s) - annulation , rhodium , chemistry , azepine , aryl , surface modification , carbene , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , alkyl
A rhodium(III)‐catalyzed [3+2]/[5+2] annulation of 4‐aryl 1‐tosyl‐1,2,3‐triazoles with internal alkynes is presented. This transformation provides straightforward access to indeno[1,7‐ cd ]azepine architectures through a sequence involving the formation of a rhodium(III) azavinyl carbene, dual C(sp 2 )H functionalization, and [3+2]/[5+2] annulation.