Premium
Palladium(II)/Brønsted Acid‐Catalyzed Enantioselective Oxidative Carbocyclization–Borylation of Enallenes
Author(s) -
Jiang Tuo,
Bartholomeyzik Teresa,
Mazuela Javier,
Willersinn Jochen,
Bäckvall JanE.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501048
Subject(s) - enantioselective synthesis , borylation , chemistry , phosphoric acid , palladium , catalysis , brønsted–lowry acid–base theory , oxidative phosphorylation , enantiomer , organic chemistry , enantiomeric excess , combinatorial chemistry , biochemistry , alkyl , aryl
An enantioselective oxidative carbocyclization–borylation of enallenes that is catalyzed by palladium(II) and a Brønsted acid was developed. Biphenol‐type chiral phosphoric acids were superior co‐catalysts for inducing the enantioselective cyclization. A number of chiral borylated carbocycles were synthesized in high enantiomeric excess.