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A Palladium(II)‐Catalyzed CH Activation Cascade Sequence for Polyheterocycle Formation
Author(s) -
Cooper Stephen P.,
BookerMilburn Kevin I.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501037
Subject(s) - palladium , thiophene , furan , chemistry , indole test , catalysis , pyrrole , combinatorial chemistry , cascade , sequence (biology) , stereochemistry , organic chemistry , biochemistry , chromatography
Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)‐catalyzed CH activation strategy for the construction of such systems has been developed. Starting from simple 1,3‐dienyl‐substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step.