A Palladium(II)‐Catalyzed CH Activation Cascade Sequence for Polyheterocycle Formation | Zendy

Cooper Stephen P. | Zendy; BookerMilburn Kevin I. | Zendy

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A Palladium(II)‐Catalyzed CH Activation Cascade Sequence for Polyheterocycle Formation

Author(s) -

Cooper Stephen P.,

BookerMilburn Kevin I.

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201501037

Subject(s) - palladium , thiophene , furan , chemistry , indole test , catalysis , pyrrole , combinatorial chemistry , cascade , sequence (biology) , stereochemistry , organic chemistry , biochemistry , chromatography

Polyheterocycles are found in many natural products and are useful moieties in functional materials and drug design. As part of a program towards the synthesis of Stemona alkaloids, a novel palladium(II)‐catalyzed CH activation strategy for the construction of such systems has been developed. Starting from simple 1,3‐dienyl‐substituted heterocycles, a large range of polycyclic systems containing pyrrole, indole, furan and thiophene moieties can be synthesized in a single step.

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