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Nickel‐Catalyzed Asymmetric Transfer Hydrogenation of Hydrazones and Other Ketimines
Author(s) -
Xu Haiyan,
Yang Peng,
Chuanprasit Pratanphorn,
Hirao Hajime,
Zhou Jianrong Steve
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201501018
Subject(s) - catalysis , nickel , transfer hydrogenation , formic acid , chemistry , organic chemistry , noyori asymmetric hydrogenation , combinatorial chemistry , enantioselective synthesis , ruthenium
We report the use of nickel catalysts for the catalytic transfer hydrogenation of hydrazones and other ketimines with formic acid. Strongly donating bisphosphines must be used to support the catalysts. As in enzymatic catalysis, attractive weak interactions may be important for stereochemical control by the nickel/binapine catalyst.