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Alkyl Aryl Ether Bond Formation with PhenoFluor
Author(s) -
Shen Xiao,
Neumann Constanze N.,
Kleinlein Claudia,
Goldberg Nathaniel W.,
Ritter Tobias
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201500902
Subject(s) - ether , aryl , chemistry , alkyl , reactivity (psychology) , williamson ether synthesis , primary (astronomy) , phenols , substrate (aquarium) , organic chemistry , medicine , oceanography , pathology , astronomy , geology , alternative medicine , physics
An alkyl aryl ether bond formation reaction between phenols and primary and secondary alcohols with PhenoFluor has been developed. The reaction features a broad substrate scope and tolerates many functional groups, and substrates that are challenging for more conventional ether bond forming processes may be coupled. A preliminary mechanistic study indicates reactivity distinct from conventional ether bond formation.