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1D NMR Homodecoupled 1 H Spectra with Scalar Coupling Constants from 2D NemoZS ‐DIAG Experiments
Author(s) -
Cotte Axelle,
Jeannerat Damien
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201500831
Subject(s) - spectral line , chemical shift , scalar (mathematics) , pulse sequence , chemistry , coupling constant , nmr spectra database , equidistant , nuclear magnetic resonance spectroscopy , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear molecule , physics , molecular physics , nuclear magnetic resonance , analytical chemistry (journal) , stereochemistry , quantum mechanics , mathematics , organic chemistry , geometry
A two‐dimensional liquid‐state NMR experiment cleanly separating chemical shifts and scalar couplings information is introduced. This DIAG experiment takes advantage of a drastic reduction of the spectral window in the indirect dimension to be quickly recorded and of a new non‐equidistant modulation of the selective pulse to improve the sensitivity of the broadband homodecoupling Zangger–Sterk sequence element by one order of magnitude. A simple automatic analysis results in 1D spectra displaying singlets and lists of the scalar couplings for first‐order multiplets. This facilitates the analysis of 1D spectra by resolving multiplets based on their differences in chemical shifts and coupling structures.