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Organocatalytic Enantioselective Oxidative CH Alkenylation and Arylation of N ‐Carbamoyl Tetrahydropyridines and Tetrahydro‐β‐carbolines
Author(s) -
Liu Xigong,
Meng Zhilin,
Li Chengkun,
Lou Hongxiang,
Liu Lei
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201500703
Subject(s) - enantioselective synthesis , chemistry , organocatalysis , combinatorial chemistry , oxidative phosphorylation , stereochemistry , catalysis , organic chemistry , biochemistry
The first organocatalytic enantioselective CH alkenylation and arylation reactions of N ‐carbamoyl tetrahydropyridines and tetrahydro‐β‐carbolines (THCs) are described. The metal‐free processes represent an efficient and straightforward approach to a variety of structurally and electronically diverse α‐substituted tetrahydropyridines and THCs in good yields with excellent regio‐ and enantioselectivities. Preliminary control experiments provide important insights into the reaction mechanism.