Premium
Nickel‐Catalyzed Amination of Aryl Chlorides with Ammonia or Ammonium Salts
Author(s) -
Green Rebecca A.,
Hartwig John F.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201500404
Subject(s) - amination , chemistry , nickel , aryl , benzonitrile , catalysis , ligand (biochemistry) , ammonia , ammonium sulfate , ammonium , organic chemistry , biochemistry , alkyl , receptor
The nickel‐catalyzed amination of aryl chlorides to form primary arylamines occurs with ammonia or ammonium sulfate and a well‐defined single‐component nickel(0) precatalyst containing a Josiphos ligand and an η 2 ‐bound benzonitrile ligand. This system also catalyzes the coupling of aryl chlorides with gaseous amines in the form of their hydrochloride salts.