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Molecular Encryption and Reconfiguration for Remodeling of Dynamic Hydrogels
Author(s) -
Li Shihui,
Gaddes Erin R.,
Chen Niancao,
Wang Yong
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201500397
Subject(s) - self healing hydrogels , ligand (biochemistry) , control reconfiguration , chemistry , adhesion , inert , cell adhesion , biophysics , nanotechnology , molecule , materials science , receptor , computer science , biochemistry , polymer chemistry , biology , organic chemistry , embedded system
Dynamic materials have been widely studied for regulation of cell adhesion that is important to a variety of biological and biomedical applications. These materials can undergo changes mainly through one of the two mechanisms: ligand release in response to chemical, physical, or biological stimuli, and ligand burial in response to mechanical stretching or the change of electrical potential. This study demonstrates an encrypted ligand and a new hydrogel that are capable of inducing and inhibiting cell adhesion, which is controlled by molecular reconfiguration. The ligand initially exhibits an inert state; it can be reconfigured into active and inert states by using unblocking and recovering molecules in physiological conditions. Since molecular reconfiguration does not require the release of the ligand from the hydrogels, inhibiting and inducing cell adhesion on the hydrogels can be repeated for multiple cycles.