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Tandem Catalytic C(sp 3 )H Amination/Sila‐Sonogashira–Hagihara Coupling Reactions with Iodine Reagents
Author(s) -
Buendia Julien,
Darses Benjamin,
Dauban Philippe
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201412364
Subject(s) - sonogashira coupling , iodine , chemistry , catalysis , reagent , amination , tandem , coupling reaction , medicinal chemistry , combinatorial chemistry , palladium , organic chemistry , materials science , composite material
A new tandem CN and CC bond‐forming reaction has been achieved through Rh II /Pd 0 catalysis. The sequence first involves an iodine(III) oxidant, then the in situ generated iodine(I) by‐product is used as a coupling partner. The overall process demonstrates the synthetic value of iodoarenes produced in trivalent iodine reagent mediated oxidations.