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Nickel‐Catalyzed Enantioselective CC Bond Formation through C sp 2 O Cleavage in Aryl Esters
Author(s) -
Cornella Josep,
Jackson Evan P.,
Martin Ruben
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201412051
Subject(s) - enantioselective synthesis , stereocenter , aryl , bond cleavage , chemistry , cleavage (geology) , catalysis , stereochemistry , nickel , substrate (aquarium) , organic chemistry , materials science , alkyl , fracture (geology) , composite material , oceanography , geology
We report the first enantioselective CC bond formation through CO bond cleavage using aryl ester counterparts. This method is characterized by its wide substrate scope and results in the formation of quaternary stereogenic centers with high yields and asymmetric induction.