Direct Trifluoromethylthiolation of Unactivated C(sp 3 )H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate | Zendy

Wu Hao | Zendy; Xiao Zhiwei | Zendy; Wu Junhui | Zendy; Guo Yong | Zendy; Xiao JiChang | Zendy; Liu Chao | Zendy; Chen QingYun | Zendy

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Direct Trifluoromethylthiolation of Unactivated C(sp 3 )H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate

Author(s) -

Wu Hao,

Xiao Zhiwei,

Wu Junhui,

Guo Yong,

Xiao JiChang,

Liu Chao,

Chen QingYun

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201411953

Subject(s) - chemistry , potassium persulfate , persulfate , selectivity , potassium , functional group , medicinal chemistry , photochemistry , organic chemistry , catalysis , polymer , polymerization

A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp 3 )H bonds by AgSCF 3 /K 2 S 2 O 8 under mild conditions is described. The reaction has a good functional‐group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K 2 S 2 O 8 plays key roles in both the activation of the C(sp 3 )H bond and the oxidation of AgSCF 3 .

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