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Direct Trifluoromethylthiolation of Unactivated C(sp 3 )H Using Silver(I) Trifluoromethanethiolate and Potassium Persulfate
Author(s) -
Wu Hao,
Xiao Zhiwei,
Wu Junhui,
Guo Yong,
Xiao JiChang,
Liu Chao,
Chen QingYun
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201411953
Subject(s) - chemistry , potassium persulfate , persulfate , selectivity , potassium , functional group , medicinal chemistry , photochemistry , organic chemistry , catalysis , polymer , polymerization
A practical and efficient method for the direct trifluoromethylthiolation of unactivated C(sp 3 )H bonds by AgSCF 3 /K 2 S 2 O 8 under mild conditions is described. The reaction has a good functional‐group tolerance and good selectivity. Initial mechanistic investigations indicate that the reaction may involve a radical process in which K 2 S 2 O 8 plays key roles in both the activation of the C(sp 3 )H bond and the oxidation of AgSCF 3 .