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Iron‐Catalyzed Asymmetric Hydrosilylation of 1,1‐Disubstituted Alkenes
Author(s) -
Chen Jianhui,
Cheng Biao,
Cao Minyi,
Lu Zhan
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201411884
Subject(s) - hydrosilylation , enantioselective synthesis , silanes , markovnikov's rule , chemistry , oxazoline , organic chemistry , catalysis , derivatization , aryl , phenol , regioselectivity , silane , alkyl , high performance liquid chromatography
Abstract The highly regio‐ and enantioselective iron‐catalyzed anti‐Markovnikov hydrosilylation of 1,1‐disubstituted aryl alkenes was developed using iminopyridine oxazoline ligands to afford chiral organosilanes. Additional derivatization of these products lead to chiral organosilanols, cyclic silanes, phenol derivatives, and 3‐substituted 2,3‐dihydrobenzofurans.