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Silver‐Mediated Oxidative Aliphatic CH Trifluoromethylthiolation
Author(s) -
Guo Shuo,
Zhang Xiaofei,
Tang Pingping
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201411807
Subject(s) - reagent , chemistry , aqueous medium , compatibility (geochemistry) , functional group , combinatorial chemistry , natural product , aqueous solution , reaction conditions , scope (computer science) , organic chemistry , catalysis , chemical engineering , computer science , engineering , programming language , polymer
Abstract The first example of a practical and direct trifluoromethylthiolation reaction of unactivated aliphatic CH bonds employs a silver‐based reagent. The reaction is operationally simple, scalable, and proceeds under aqueous conditions in air. Furthermore, its broad scope and good functional‐group compatibility were demonstrated by applying this method to the selective trifluoromethylthiolation of natural products and natural‐product derivatives.