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Antitumor Drug Delivery Modulated by A Polymeric Micelle with an Upper Critical Solution Temperature
Author(s) -
Li Weishuo,
Huang Liwen,
Ying Xiaoying,
Jian You,
Hong Yuan,
Hu Fuqiang,
Du Yongzhong
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201411524
Subject(s) - lower critical solution temperature , upper critical solution temperature , nanocarriers , micelle , drug delivery , polymer , amphiphile , materials science , critical micelle concentration , chemical engineering , thermoresponsive polymers in chromatography , chemistry , peg ratio , nanotechnology , aqueous solution , copolymer , organic chemistry , phase (matter) , finance , economics , reversed phase chromatography , engineering
Thermally sensitive polymeric nanocarriers were developed to optimize the release profile of encapsulated compounds to improve treatment efficiency. However, when referring to thermally sensitive polymeric nanocarriers, this usually means systems fabricated from lower critical solution temperature (LCST) polymers, which have been intensively studied. To extend the field of thermally sensitive polymeric nanocarriers, we for the first time fabricated a polymeric drug delivery system having an upper critical solution temperature (UCST) of 43 °C based on an amphiphilic polymer poly(AAm‐co‐AN)‐g‐PEG. The resulting polymeric micelles could effectively encapsulate doxorubicin and exhibited thermally sensitive drug release both in vitro and in vivo. A drastically improved anticancer efficiency (IC 50 decreased from 4.6 to 1.6 μg mL −1 , tumor inhibition rate increased from 55.6 % to 92.8 %) was observed. These results suggest that UCST‐based drug delivery can be an alternative to thermally sensitive LCST‐based drug delivery systems for an enhanced antitumor efficiency.