Premium
Rapid Formation of a Supramolecular Polypeptide–DNA Hydrogel for In Situ Three‐Dimensional Multilayer Bioprinting
Author(s) -
Li Chuang,
FaulknerJones Alan,
Dun Alison R.,
Jin Juan,
Chen Ping,
Xing Yongzheng,
Yang Zhongqiang,
Li Zhibo,
Shu Wenmiao,
Liu Dongsheng,
Duncan Rory R.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201411383
Subject(s) - biocompatibility , supramolecular chemistry , materials science , biomaterial , in situ , nanotechnology , 3d bioprinting , tissue engineering , self healing hydrogels , 3d printed , biomedical engineering , chemistry , polymer chemistry , molecule , medicine , organic chemistry , metallurgy
A rapidly formed supramolecular polypeptide–DNA hydrogel was prepared and used for in situ multilayer three‐dimensional bioprinting for the first time. By alternative deposition of two complementary bio‐inks, designed structures can be printed. Based on their healing properties and high mechanical strengths, the printed structures are geometrically uniform without boundaries and can keep their shapes up to the millimeter scale without collapse. 3D cell printing was demonstrated to fabricate live‐cell‐containing structures with normal cellular functions. Together with the unique properties of biocompatibility, permeability, and biodegradability, the hydrogel becomes an ideal biomaterial for 3D bioprinting to produce designable 3D constructs for applications in tissue engineering.