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Chirality‐Assisted Ring‐Like Aggregation of Aβ(1 – 40) at Liquid–Solid Interfaces: A Stereoselective Two‐Step Assembly Process
Author(s) -
Gao Guanbin,
Zhang Mingxi,
Lu Pei,
Guo Guanlun,
Wang Dong,
Sun Taolei
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201410768
Subject(s) - chirality (physics) , chemistry , stereoselectivity , nanoscopic scale , ring (chemistry) , electrostatics , substrate (aquarium) , raman scattering , raman spectroscopy , adsorption , crystallography , nanotechnology , chemical physics , materials science , chiral symmetry , organic chemistry , optics , catalysis , physics , geology , nambu–jona lasinio model , quark , oceanography , quantum mechanics
Molecular chirality is introduced at liquid–solid interfaces. A ring‐like aggregation of amyloid Aβ(1–40) on N ‐isobutyryl‐ L ‐cysteine ( L ‐NIBC)‐modified gold substrate occurs at low Aβ(1–40) concentration, while D ‐NIBC modification only results in rod‐like aggregation. Utilizing atomic force microscope controlled tip‐enhanced Raman scattering, we directly observe the secondary structure information for Aβ(1–40) assembly in situ at the nanoscale. D ‐ or L ‐NIBC on the surface can guide parallel or nonparallel alignment of β‐hairpins through a two‐step process based on electrostatic‐interaction‐enhanced adsorption and subsequent stereoselective recognition. Possible electrostatic interaction sites (R5 and K16) and a chiral recognition site (H14) of Aβ(1–40) are proposed, which may provide insight into the understanding of this effect.