Highly Enantioselective Nickel‐Catalyzed Intramolecular Reductive Cyclization of Alkynones | Zendy

Fu Wenzhen | Zendy; Nie Ming | Zendy; Wang Aizhen | Zendy; Cao Ziping | Zendy; Tang Wenjun | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Highly Enantioselective Nickel‐Catalyzed Intramolecular Reductive Cyclization of Alkynones

Author(s) -

Fu Wenzhen,

Nie Ming,

Wang Aizhen,

Cao Ziping,

Tang Wenjun

Publication year - 2015

Publication title -

angewandte chemie

Language(s) - English

Resource type - Journals

eISSN - 1521-3757

pISSN - 0044-8249

DOI - 10.1002/ange.201410700

Subject(s) - enantioselective synthesis , chemistry , intramolecular force , nickel , triethylsilane , allylic rearrangement , reagent , furan , combinatorial chemistry , substrate (aquarium) , pyran , catalysis , ligand (biochemistry) , organic chemistry , oceanography , receptor , geology , biochemistry

The first asymmetric nickel‐catalyzed intramolecular reductive cyclization of alkynones is reported. A P‐chiral monophosphine and triethylsilane were used as the ligand and the reducing reagent, respectively, to form a series of tertiary allylic alcohols bearing furan/pyran rings in excellent yields and enantioselectivities. This reaction has a broad substrate scope and enabled the efficient synthesis of dehydroxycubebin and chiral dibenzocyclooctadiene skeletons.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research