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General Method for the Synthesis of Salicylic Acids from Phenols through Palladium‐Catalyzed Silanol‐Directed CH Carboxylation
Author(s) -
Wang Yang,
Gevorgyan Vladimir
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201410375
Subject(s) - carboxylation , silanol , chemistry , palladium , catalysis , surface modification , phenols , organic chemistry , selectivity , combinatorial chemistry
A silanol‐directed, palladium‐catalyzed CH carboxylation reaction of phenols to give salicylic acids has been developed. This method features high efficiency and selectivity, and excellent functional‐group tolerance. The generality of this method was demonstrated by the carboxylation of estrone and by the synthesis of an unsymmetrically o , o ′‐disubstituted phenolic compound through two sequential CH functionalization processes.