Premium
Nickel‐Catalyzed Dehydrogenative Cross‐Coupling: Direct Transformation of Aldehydes into Esters and Amides
Author(s) -
Whittaker Aaron M.,
Dong Vy M.
Publication year - 2015
Publication title -
angewandte chemie
Language(s) - English
Resource type - Journals
eISSN - 1521-3757
pISSN - 0044-8249
DOI - 10.1002/ange.201410322
Subject(s) - aldehyde , catalysis , nickel , catalytic cycle , chemistry , coupling (piping) , combinatorial chemistry , oxidative coupling of methane , organic chemistry , oxidative phosphorylation , materials science , biochemistry , metallurgy
By exploring a new mode of nickel‐catalyzed cross‐coupling, a method to directly transform both aromatic and aliphatic aldehydes into either esters or amides has been developed. The success of this oxidative coupling depends on the appropriate choice of catalyst and organic oxidant, including the use of either α,α,α‐trifluoroacetophenone or excess aldehyde. Mechanistic data that supports a catalytic cycle involving oxidative addition into the aldehyde CH bond is also presented.